Tania Melnyczuk

Study notes

My Study Notes record what I am learning. They're mostly about molecular and cell biology. They reflect my knowledge and understanding at the time, and are subject to extensive revision.

Phosphatidylcholine, acetyl-l-carnitine and magnesium for managing bipolar states

Phosphatidylcholine, acetyl-l-carnitine and magnesium for managing bipolar states

Briefly: I am developing a hypothesis (and an outline study design) for the management of bipolar states through the supplementation of phosphatidylcholine at the onset of a manic phase, and acetyl-l-carnitine at the onset of a depressive phase, to even out the peaks and troughs. The full regime would involve a low-carbohydrate medium-fat diet (not LCHF), and symptom-dependent ad hoc magnesium supplementation. This is a management regime, not a ‘cure’.

My hypothesis here is (inter alia) that optimising liver function will help to clear some of the substances (I am going to have to look up what they are) which correlate to mania… and I don’t have time to type up all the rest of this now, but here are some of the links I’ve collected to check through.

Here’s part of the problem:
I found one specificically on bipolar mania some time ago, though. Will continue to hunt for that.


Caroline Attwood




Max Delsid

Yes, I know biopolar depression and other depression are not necessarily the same thing, but gimme time to get beyond my confirmation bias, OK?


But also:



A key point here is that we’re talking about intracellular magnesium, and its regulation via the calcium-magnesium pump and ion channels. This links to my study on sensory overload.

More later. But probably much later, because the other paper must be finished before I can devote time to this.

Bicistronic genes… ummm!

Bicistronic genes… ummm!

Here’s the challenge: I now need to understand what cistrons are. I know what loci means, sort of. It means ‘places’. But, having looked up loci, I see that it has quite a specific meaning in genetics.

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